![]() ![]() ![]() The range of diseases caused by these fungi is broad, ranging from transient colonization of the respiratory tract to saprophytic involvement of abnormal airways, allergic bronchopulmonary reaction, invasive localized disease, and at times disseminated disease. Infections caused by these organisms can be localized, extend to the surrounding tissues (deep extension), or disseminate (hematogenously) to distant organs. These fungi can be colonizers of previously damaged bronchopulmonary trees (as in old pulmonary tuberculosis cases, cystic fibrosis, or bronchiectatic lungs of any etiology). Scedosporiosis represents a broad spectrum of clinical diseases caused by the agents of the genus Scedosporium. prolificans are ubiquitous filamentous fungi present in soil, sewage, and polluted waters. The genus Scedosporium consists of two medically important species: Scedosporium apiospermum (and its teleomorph or sexual state Pseudallescheria boydii) and Scedosporium prolificans (formerly S. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans seldom respond to medical therapy alone. boydii in patients and animals may respond to antifungal triazoles. Molecular tools for clinical microbiological detection of Scedosporium spp. currently depends upon culture and morphological characterization. Microbiological diagnosis of Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Studies of the pathogenesis of and immune response to Scedosporium spp. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. ![]() apiospermum, is recognized by the presence of cleistothecia. Pseudallescheria boydii, the teleomorph of S. ![]() Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. ![]()
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